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. 2023 Jan 28;11(1):e01056. doi: 10.1002/prp2.1056

FIGURE 3.

FIGURE 3

15‐oxylipins inhibit 12‐LOX activity. The levels of (A) 12‐HETE (DMSO = 1.0 ± 0; 15‐HETrE = 0.56 ± 0.139; 15‐HETE = 0.04 ± 0.009; 15‐HEPE = 0.11 ± 0.009) and (B) TXB2 (DMSO = 1.0 ± 0; 15‐HETrE = 1.03 ± 0.137; 15‐HETE = 0.93 ± 0.312; 15‐HEPE = 1.0 ± 0.134) were quantified in the lysate of collagen‐stimulated (5 μg/mL) platelets (n = 5) pretreated with 15‐ HETE (10 μM), 15‐HETrE (10 μM), or 15‐HETE (10 μM). One‐way ANOVA with Dunnett's multiple comparison post hoc test. Data represent mean ± SD. ****p < 0.0001. DMSO concentration corresponds to the residual DMSO in the 10 μM oxylipin sample.