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Clinical Trial Concept 1: Inhibitor Prevention: Emicizumab plus FVIII vs FVIII Alone in PUPs Trial. Previously untreated patients (PUPs) with severe haemophilia A are randomized to receive weekly emizicumab plus FVIII vs weekly FVIII alone and are followed for inhibitor formation >5.0 BU at prespecified time-points for 48 wk
