Figure 19.
The propensity for cycloaddition with azides is increased in cycloalkynes by the destabilization of the alkyne by proximal electron withdrawing groups (e.g. fluorine atoms) and by the increase of sp2 hybridized atoms in the ring.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.