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Treatments groups
| Group | Treatment regimen | Treatment | Tablets per day |
|---|---|---|---|
| 1 | 2 mg BI 425809 QD | 1 mg | 2-0-0 |
| 25 mg PTM | 1-0-0 | ||
| 2 | 5 mg BI 425809 QD | 5 mg | 1-0-0 |
| 1 and 5 mg PTM | 1-0-0 | ||
| 25 mg PTM | 1-0-0 | ||
| 3 | 10 mg BI 425809 QD | 5 mg | 2-0-0 |
| 25 mg PTM | 1-0-0 | ||
| 4 | 25 mg BI 425809 QD | 1 and 5 mg PTM | 2-0-0 |
| 25 mg | 1-0-0 | ||
| 5 | Placebo QD | 1 and 5 mg PTM | 2-0-0 |
| 25 mg PTM | 1-0-0 |
PTM placebo to match, QD once daily
