Table 2.
Influx and efflux time constants of the AD clusters. p-values of the two-sample t-test performed on the time constants τin and τout (reported as mean ± sem [min] across animals) for the influx and the efflux of the DOTAREM for the AD clusters. *p < 0.05; #trend for statistical significance
| Cluster | AD1 | AD2 | AD3 | AD4 | AD5 | AD6 | AD7 | AD8 | AD9 | AD10 |
|---|---|---|---|---|---|---|---|---|---|---|
| p-value (in) = | 0.2868 | 0.0209* | 0.0204* | 0.0327* | 0.0563# | 0.4011 | 0.0260* | 0.1161 | 0.1541 | 0.6050 |
| τin (CTL) [min] | 3.0 ± 1.8 | 3.5 ± 1.7 | 4.0 ± 1.9 | 3.3 ± 1.4 | 2.5 ± 1.6 | 9.7 ± 3.0 | 2.6 ± 1.7 | 1.6 ± 0.9 | 0.8 ± 0.1 | 0.8 ± 0.1 |
| τin (AD) [min] | 9.1 ± 5.1 | 25.0 ± 7.3 | 23.6 ± 6.5 | 19.6 ± 6.2 | 12.9 ± 4.4 | 13.8 ± 3.4 | 21.9 ± 6.9 | 9.7 ± 4.5 | 2.7 ± 1.1 | 0.7 ± 0.1 |
| p-value (out) = | 0.5503 | 0.7787 | 0.2947 | 0.7097 | 0.4027 | 0.3415 | 0.8662 | 0.2634 | 0.1631 | 0.9691 |
| τout (CTL) [min] | 77.3 ± 32.5 | 54.3 ± 7.0 | 43.5 ± 8.4 | 69.6 ± 17.9 | 60.5 ± 9.5 | 179.5 ± 20.5 | 56.8 ± 8.6 | 55.8 ± 10.1 | 41.8 ± 6.1 | 34.3 ± 2.8 |
| τout (AD) [min] | 56.9 ± 3.5 | 56.4 ± 2.6 | 53.0 ± 1.2 | 62.5 ± 3.8 | 71.9 ± 8.7 | 132.5 ± 41.8 | 55.2 ± 3.1 | 92.0 ± 28.3 | 92.0 ± 32.2 | 33.9 ± 8.5 |