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. 2023 Jan 28;21:32. doi: 10.1186/s12951-023-01775-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — a Confocal images of an in vitro BBB model after incubation with represented for NPs size ranging from 25 to 100 nm [63]; b combined chemo-immunotherapeutic nanoparticles (DOX@MSN-SS-iRGD&1MT) through MSNs-based drug delivery system [96]; c Mechanism of tracking drug delivery (Ru@Pen@PEG-AuNS) for AD therapy [97]; d Permeability coefficient of AgNPs and TiO₂ NPs are both used [98]