TABLE 3.
Autism risk by birthweight percentile after multivariate analysis
| Variable | aOR | 95% CI | 95% Wald | |
|---|---|---|---|---|
|
| ||||
| Birthweight percentile | ||||
| <5% | 1.10 | 1.04–1.18 | 1.04 | 1.18 |
| 5–10% | 1.04 | 0.98–1.11 | 0.98 | 1.11 |
| >10 to <90% | 1.00 | Reference | ||
| 90–95% | 1.04 | 0.97–1.10 | 0.97 | 1.10 |
| >95% | 1.12 | 1.05–1.19 | 1.05 | 1.19 |
| Multivariate analysis | ||||
| Maternal preeclampsia | 1.11 | 0.95–1.29 | 0.95 | 1.29 |
| Maternal hypertension | 1.09 | 0.95–1.25 | 0.95 | 1.25 |
| Maternal diabetes | 1.22 | 1.15–1.30 | 1.15 | 1.30 |
| Maternal age | ||||
| ≤20 | 0.58 | 0.55–0.61 | 0.55 | 0.61 |
| 21–25 | 1.00 | Reference | ||
| 26–30 | 1.3 5 | 1.30–1.40 | 1.30 | 1.40 |
| 30–35 | 1.76 | 1.69–1.83 | 1.69 | 1.83 |
| 35–40 | 2.19 | 2.09–2.30 | 2.09 | 2.30 |
| ≥41 | 2.42 | 2.22–2.65 | 2.22 | 2.65 |
| Twin gestation | 1.56 | 1.41–1.73 | 1.41 | 1.73 |
| Birth order | ||||
| 1 | 1.0 | Referenee; | ||
| 2 | 0.62 | 0.50–0.76 | 0.50 | 0.76 |
| ≥3 | 1.13 | 0.42–3.05 | 0.44 | 3.19 |
| Unknown | 1.18 | 1.14–1.23 | 1.14 | 1.23 |
| Race | ||||
| Non-hispanic white | 1.00 | Reference | Reference | |
| Hispanic | 0.83 | 0.80–0.86 | 0.80 | 0.86 |
| African American | 1.19 | 1.13–1.25 | 1.13 | 1.25 |
| Asian | 1.15 | 1. 10–1. 19 | 1. 10 | 1. 19 |
| Other | 0.72 | 0.63–0.83 | 0.63 | 0.83 |
| Time since last live birth | ||||
| Missing | 1.74 | 1.67–1.82 | 1.67 | 1.82 |
| 0–1 5 y | 1.89 | 1.78–2.02 | 1.78 | 2.02 |
| 1.5–2.5 y | 1.60 | 1.52–1.69 | 1.52 | 1.69 |
| 2.5–4 y | 1.00 | Reference | Reference | |
| 4–6 y | 0.81 | 0.75–0.86 | 0.75 | 0.86 |
| ≥6 y | 0.99 | 0.94–1.06 | 0 94 | 1.06 |
aOR, adjusted odds ratio; CI, confidence interval.
Moore. Autism risk by birthweight percentile. Am J Obstet Gynecol 2012.