Fig. 1.

Demonstrative examples of COVID-19 infection. The patients were divided into four main groups based on the severity of COVID-19 infection: mild, moderate, severe, and critical. Both CASP8 2^−ΔΔCt and CASP8 levels of patients were detected. The COVID-19 infection causes cellular damage, and a response occurs in the nucleus of cells. The CASP8 gene is transcribed CASP8 mRNA, and CASP8 proteins are translated from mature CASP8 mRNA. The ELISA standard curve is presented in Fig. 1(a). Statistically significant differences were detected among all groups for CASP8 2^−ΔΔCt levels. As the severity of COVID-19 infection increased, the expression level of CASP8 gene significantly decreased. Considering the CASP8 gene expression level in the pairwise comparison, there were statistically significant differences between mild and severe, mild and critical, moderate and severe, moderate and critical groups [Fig. 1(b)]. Serum caspase8 levels of groups are shown in Fig. 1(c). As the severity of COVID-19 infection increased, the serum CASP8 levels significantly decreased. There was a statistically significant difference between mild and critical and between moderate and critical groups in terms of serum CASP8 levels