Fig. 2.

Demonstrative examples of COVID-19 infection. The patients were divided into four main groups based on the severity of COVID-19 infection: mild, moderate, severe, and critical. Both MAPK1 2^−ΔΔCt and MAPK1 levels of patients were detected. The COVID-19 infection causes cellular damage, and a response occurs in the nucleus of cells. MAPK1 gene is transcribed MAPK1mRNA, and MAPK1 proteins are translated from mature MAPK1 mRNA. The ELISA standard curve is presented in Fig. 2(a). Statistically significant differences were detected among all groups for MAPK1 2^−ΔΔCt levels. As the severity of COVID-19 infection increased, the expression level of the MAPK1 gene significantly decreased. Considering the MAPK1 gene expression level in a pairwise comparison, there was a statistically significant difference between mild and critical and between moderate and critical groups [Fig. 2(b)]. Serum MAPK1 levels of groups are presented in Fig. 2(c). When the severity of COVID-19 infection increased, the serum level significantly decreased. Considering the serum MAPK1 levels in pairwise comparison, there was no statistically significant differences between the groups