Table 6.
Assay results for the determination of four studied drugs in their co-formulated prepared tablet by the suggested HPLC technique.
Ratio | Suggested technique | Comparison method23 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Concentration taken (µg/mL) | Concentration found (µg/mL) | % Found | % Found | |||||||||||||
PAR | LVC | PHN | AMB | PAR | LVC | PHN | AMB | PAR | LVC | PHN | AMB | PAR | LVC | PHN | AMB | |
65:1:1:6 | 325.0 | 5.0 | 5.0 | 30.0 | 320.886 | 5.064 | 4.953 | 30.457 | 98.73 | 101.28 | 99.06 | 101.52 | 101.93 | 98.90 | 101.92 | 98.58 |
390.0 | 6.0 | 6.0 | 36.0 | 397.759 | 5.901 | 6.051 | 35.208 | 101.99 | 98.35 | 100.85 | 97.8 | 99.54 | 101.21 | 98.43 | 101.50 | |
455.0 | 7.0 | 7.0 | 42.0 | 451.271 | 7.043 | 6.981 | 42.361 | 99.18 | 100.61 | 99.73 | 100.86 | 100.12 | 99.58 | 100.49 | 99.49 | |
Mean | 99.97 | 100.08 | 99.88 | 100.06 | 100.53 | 99.19 | 100.28 | 99.85 | ||||||||
± S.D | 1.77 | 1.54 | 0.91 | 1.99 | 1.25 | 1.19 | 1.754 | 1.49 | ||||||||
t-test | 0.45 | 0.16 | 0.35 | 0.075 | The tabulated t and F values are 2.78 and 19.00, respectively at P = 0.0542 | |||||||||||
F-test | 2.01 | 1.68 | 3.76 | 1.76 |