Table 2. 2-Methyl-pyrimidine Core SARa.

Each Ki value reported is an average of at least two measurements with a 10-point dose–response curve. Rat CLu was calculated by dividing measured rat clearance by rat plasma free fraction.

Each Ki value reported is an average of at least two measurements with a 10-point dose–response curve. Rat CLu was calculated by dividing measured rat clearance by rat plasma free fraction.