. 2023 Jan 10;66(2):1157–1171. doi: 10.1021/acs.jmedchem.2c01521

Table 3. Pharmacokinetic Profile of 18 in Rats and Rhesus Monkeys^a.

Species	CL_p (mL/min/kg)	Vd_ss (L/kg)	T_1/2 (h)	F (%)
Rat	21.3	0.93	4.8	46
Rhesus	9.3	1.4	4.2	41

Data represent mean values (n = 3). Rats were dosed 2 mg/kg IV and 10 mg/kg PO; rhesus were dosed 0.5 mg/kg IV and 5 mg/kg PO.

Table 3. Pharmacokinetic Profile of 18 in Rats and Rhesus Monkeysa.