Table 4. MK-8189 (18) Dose, Plasma Exposure, and Striatal Occupancy Derived from Plasma Taken at the End of Rat Behavioral Studies.
| Rodent model | MK-8189 (18) dose (mg/kg) | Plasma at the end of the study (nM) | PDE10A Occ (%) derived from plasma |
|---|---|---|---|
| MK-801-induced locomotor activitya | 0.25 | 17 (4) | 25 (5) |
| 0.50 | 36 (10) | 41 (11) | |
| 0.75 | 50 (16) | 50 (16) | |
| Novel objection recognitionb | 0.08 | 16 (4) | 24 (6) |
| 0.16 | 18 (4) | 29 (6) | |
| 0.25 | 29 (8) | 34 (9) | |
a
Values reported as Mean (SEM), n = 8/group, and plasma samples taken 2.5 h post dose.
b
Values reported as Mean (SEM), n = 4/group, and plasma samples taken 1 h post dose.