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. 2023 Jan 12;66(2):1380–1425. doi: 10.1021/acs.jmedchem.2c01597

Scheme 2. Synthesis of Hydrazide 15.

Scheme 2

Reagents and conditions: (a) tert-butyl carbazate, TBTU, DMF, N-methylmorpholine, 22 °C, 8 h; (b) 4 M HCl in 1,4-dioxane, 22 °C, 24 h.