. 2023 Jan 12;66(2):1380–1425. doi: 10.1021/acs.jmedchem.2c01597

Table 1. IC₅₀ Values against E. coli, A. baumannii, and P. aeruginosa DNA Gyrase and Topoisomerase IV, MICs, Solubility, and Free Fraction Data of Analogs of the Frontrunner 1 with Replaced or Substituted Phenyl Moiety.

2.1.1.1.

E. coli ATCC5922 (wild type), CH3130 (efflux-defective; ΔtolC-mutant isogenic to ATCC25922).

A. baumannii ATCC19606 (wild type), BM4652 (efflux-defective derivative of BM4454).

P. aeruginosa PAO1 (wild type), PAO750 (efflux-defective isogenic to PAO1).

Kinetic solubility.

Thermodynamic solubility.

Gel-based assay.

The results should be interpreted carefully due to low recovery; TPSA, total polar surface area; Calc., calculated; n.d., not determined; WT, wild type; Δeff., efflux-defective strain.

Table 1. IC50 Values against E. coli, A. baumannii, and P. aeruginosa DNA Gyrase and Topoisomerase IV, MICs, Solubility, and Free Fraction Data of Analogs of the Frontrunner 1 with Replaced or Substituted Phenyl Moiety.

Table 1. IC₅₀ Values against E. coli, A. baumannii, and P. aeruginosa DNA Gyrase and Topoisomerase IV, MICs, Solubility, and Free Fraction Data of Analogs of the Frontrunner 1 with Replaced or Substituted Phenyl Moiety.