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. 2023 Jan 12;66(2):1380–1425. doi: 10.1021/acs.jmedchem.2c01597

Table 2. IC50 Values against E. coli, A. baumannii, and P. aeruginosa DNA Gyrase and Topoisomerase IV, MICs, Solubility, and Free Fraction Data of the N-Alkylated Analogs.

2.1.1.4.

2.1.1.4.

a

E. coli ATCC5922 (wild type), CH3130 (efflux-defective; ΔtolC-mutant isogenic to ATCC25922).

b

A. baumannii ATCC19606 (wild type), BM4652 (efflux-defective derivative of BM4454).

c

P. aeruginosa PAO1 (wild type), PAO750 (efflux-defective isogenic to PAO1).

d

Kinetic solubility.

e

Gel-based assay.

f

The results should be interpreted carefully due to low recovery; TPSA, total polar surface area; Calc., calculated; n.d., not determined; WT, wild type; Δeff., efflux-defective strain.