Table 4. MIC Values of Compound 27 and Selected Derivatives against Some Multiresistant Strains of A. baumannii and P. aeruginosa.
| strain ID | species | original no. | genotype/phenotype | 27 | 30 | 31 | 34 | 35 | 36 | 46 | 47 | 48 | 51 | 65 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EN7 | A. baumannii | ATCC19606 | WT | 1 | 16 | 1 | 8 | 4 | 4 | 2 | 1 | 2 | 1 | 2 |
| EN16 | A. baumannii | BM4454 | WT | 0.5 | 8 | 0.5 | 8 | 4 | 2 | 2 | 1 | 1 | 1 | 4 |
| EN17 | A. baumannii | BM4652 | efflux-defective | 0.5 | 0.125 | 0.125 | 0.125 | 0.25 | 0.5 | 0.5 | 1 | 1 | 2 | 1 |
| EN273 | A. baumannii | NMI 2692/14 | clinical MDR | 1 | 8 | 0.5 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 4 |
| EN274 | A. baumannii | NMI 2699/14 | clinical MDR | 1 | 64 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 8 |
| EN276 | A. baumannii | NMI 2704/14 | clinical MDR | 1 | 4 | 0.5 | 2 | 1 | 2 | 2 | 1 | 2 | 2 | 4 |
| EN277 | A. baumannii | NMI 2715/14 | clinical MDR | 1 | 16 | 1 | 1 | 4 | 4 | 4 | 4 | 4 | 2 | 8 |
| CH8730 | A. baumannii | CH8730 | gyrB R150C | 8 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 |
| EN0146 | P. aeruginosa | NMI 3793/07 | clinical MDR | 1 | 16 | 1 | 8 | 8 | 4 | 8 | 2 | 4 | 4 | 8 |
| EN0147 | P. aeruginosa | NMI 2500/14 | clinical MDR | 1 | >64 | 1 | 8 | 8 | 4 | 8 | 1 | 4 | 2 | 8 |
| EN0148 | P. aeruginosa | RYC 03131390 | clinical MDR | 2 | 32 | 2 | 16 | 16 | 8 | 32 | 4 | 8 | 4 | 64 |
| EN0149 | P. aeruginosa | NMI 2620/03 | clinical MDR | 1 | 32 | 0.5 | 16 | 8 | 2 | 8 | 1 | 2 | 2 | 8 |
| EN0340 | P. aeruginosa | 3947/14 | clinical MDR | 1 | 16 | 1 | 8 | 8 | 4 | 8 | 2 | 4 | 4 | 8 |
| EN0343 | P. aeruginosa | 3957/14 | clinical MDR | 1 | 64 | 1 | 16 | 16 | 2 | 8 | 2 | 2 | 2 | 16 |
| CH9393 | P. aeruginosa | CH9393 | gyrB R138C | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 |
| CH9389 | E. coli | CH9389 | gyrB R136H | >64 | >64 | >64 | >64 | >64 | 64 | >64 | >64 | >64 | >64 | >64 |