. 2023 Jan 12;66(2):1380–1425. doi: 10.1021/acs.jmedchem.2c01597

Table 5. IC₅₀ Values against E. coli, A. baumannii, and P. aeruginosa DNA Gyrase and Topoisomerase IV, MICs, Solubility, and Free Fraction Data of Derivatives of Compound 27, Active against Gram-Negative Bacteria.

2.1.2.

E. coli ATCC5922 (wild type), CH3130 (efflux-defective; ΔtolC-mutant isogenic to ATCC25922).

A. baumannii ATCC19606 (wild type), BM4652 (efflux-defective derivative of BM4454).

P. aeruginosa PAO1 (wild type), PAO750 (efflux-defective isogenic to PAO1).

Kinetic solubility.

Thermodynamic solubility.

Gel-based assay.

The results should be interpreted carefully due to low recovery; TPSA, total polar surface area; Calc., calculated; n.d., not determined; WT, wild type; Δeff., efflux-defective strain.

Table 5. IC50 Values against E. coli, A. baumannii, and P. aeruginosa DNA Gyrase and Topoisomerase IV, MICs, Solubility, and Free Fraction Data of Derivatives of Compound 27, Active against Gram-Negative Bacteria.

Table 5. IC₅₀ Values against E. coli, A. baumannii, and P. aeruginosa DNA Gyrase and Topoisomerase IV, MICs, Solubility, and Free Fraction Data of Derivatives of Compound 27, Active against Gram-Negative Bacteria.