Skip to main content
. Author manuscript; available in PMC: 2023 Jan 28.
Published in final edited form as: J Control Release. 2022 Sep 7;350:668–687. doi: 10.1016/j.jconrel.2022.08.051

Table 1.

Structural attributes of drug molecules for BBB penetration.

Properties Requirements Examples References
Molecular weight <450 [98]
cLogP 2 < cLogP <4 Crizotinib [99]
Hydrogen bonds donor HBD < 3 Compound 6 [100,101]
pKa 6 <<10.5 Compound 37 [98]
tPSA (Topological polar surface area) <90 Å Compound 3 [102,103]