. Author manuscript; available in PMC: 2023 Jan 28.

Published in final edited form as: J Control Release. 2022 Sep 7;350:668–687. doi: 10.1016/j.jconrel.2022.08.051

Table 2.

Different nanomedicine for improving BBB transport.

SN	Targeting ligand	model/Species	Disease	Outcome	Reference

1	LRP	mice	MB	Improved efficacy	[123]
2	Angiopeps	In vitro, mice, human	Normal	High permeability	[118]
3	nAChRs	Nude mice	GBM	Improved efficacy	[112]
4	TfR	In vitro and mice	GBM	Increase in survival	[124]
5	Chlorotoxin	Mice	Inflammation	Imaging, efficacy	[125]
6	MiniAp-4	BBB model, mice	Normal	Increased permeation	[126]