Table 2.
Baseline Gastrointestinal Symptoms and Sigmoidoscopy Findings of Schistosome-infected and Uninfected Adults.
| Patient characteristic |
S. mansoni-infected (n=32) |
S. mansoni-uninfected (n=16) |
|---|---|---|
| Number (%) or Median [IQR] |
Number (%) or Median [IQR] |
|
| Abdominal pain in past week | ||
| No | 11 (34.4%) | 8 (50%) |
| Somewhat | 14 (43.8%) | 6 (37.5%) |
| Very much | 7 (21.8%) | 2 (12.5%) |
| Constipation in past week | ||
| No | 24 (75%) | 13 (81.2%) |
| Somewhat | 5 (15.6%) | 2 (12.5%) |
| Very much | 2 (6.3%) | 1 (6.3%) |
| Did not answer | 1 (3.1%) | 0 |
| Increased frequency of stool in past week | ||
| Normal | 28 (87.5%) | 13 (81.2%) |
| 1-2 times more than usual | 3 (9.4%) | 2 (12.5%) |
| 3-4 times more than usual | 1 (3.1%) | 1 (6.3%) |
| Blood in stool in past week | ||
| No | 24 (75%) | 14 (87.5%) |
| Somewhat (<50% of the time) | 5 (15.6%) | 0 |
| Very much (>50% of the time) | 2 (6.3%) | 2 (12.5%) |
| Did not answer | 1 (3.1%) | 0 |
| Overall endoscopy findings *** | ||
| Normal (0) | 1 (3.1%) | 7 (43.8%) |
| Mild disease (1) | 25 (78.1%) | 9 (56.2%) |
| Moderate disease (2) | 6 (18.8%) | 0 |
| Severe disease (3) | 0 | 0 |
| Physician’s Overall Rating of Disease Severity *** | ||
| Normal (0) | 1 (3.1%) | 7 (43.8%) |
| Mild (1) | 25 (78.1%) | 9 (56.2%) |
| Moderate (2) | 5 (15.6%) | 0 |
| Severe (3) | 1 (3.1%) | 0 |
| Mayo score ** | 2 [2-4] | 2 [0-2] |
| Sigmoid colon mucosal features | ||
| Mild disease | ||
| Patchy or mild erythema* | 8 (25%) | 0 |
| Altered vascular pattern** | 18 (56.2%) | 2 (12.5%) |
| Mild friability | 5 (15.6%) | 1 (6.3%) |
| Moderate disease | ||
| Marked erythema | 1 (3.1%) | 0 |
| Absent vascular markings | 2 (6.3%) | 0 |
| Moderate friability | 2 (6.3%) | 0 |
| Erosions | 1 (3.1%) | 0 |
| Overall sigmoid mucosal findings*** | 1 [0-1] | 0 [0-0] |
| (0=Normal, 1=Mild, 2=Moderate, 3=Severe) | ||
| Rectum mucosal features | ||
| Mild | ||
| Patchy or mild erythema** | 19 (59.4%) | 2 (12.5%) |
| Altered vascular pattern | 24 (75%) | 7 (43.8%) |
| Mild friability | 10 (31.2%) | 1 (6.3%) |
| Moderate | ||
| Marked erythema | 5 (15.6%) | 0 |
| Absent vascular markings | 3 (9.4%) | 0 |
| Moderate friability | 6 (18.8%) | 0 |
| Erosions | 2 (6.3%) | 0 |
| Overall rectal mucosal findings*** | 1 [1-1] | 1 [0-1] |
| (0=Normal, 1=Mild, 2=Moderate, 3=Severe) | ||
| Comparison of gastrointestinal sites *** | ||
| Mucosal abnormalities greater in rectum than sigmoid | 11 (34.4%) | 7 (43.8%) |
| Mucosal abnormalities equivalent between rectum and sigmoid | 20 (62.5%) | 2 (12.5%) |
| Normal mucosa at rectum and sigmoid | 1 (3.1%) | 7 (43.8%)# |
*
p-value < 0.05
**
p-value < 0.01
***
p-value < 0.001
#
Includes two women and three men who had normal rectal and sigmoid mucosa aside from abnormal findings isolated to the distal rectum.