Table 3.
Cleared infection |
Infected but had >7-fold decrease in CAA |
Infected and did not have at least 7-fold decrease in CAA |
Uninfected at baseline and stayed uninfected |
Uninfected at baseline and became infected at month 6 |
|
---|---|---|---|---|---|
No. of individuals | 7 | 7 | 5 | 6 | 3 |
Female | 7 (100%) | 5 (71.4%) | 2 (40%) | 2 (33.3%) | 3 (100%) |
Median [IQR] CAA fold change from baseline to month 6 | −641 [−23.7 to −5190] | −85.3 [−29.6 to −296.1] | −3.2 [−2.9 to −6.8] | n/a | +62 [+58 to +80] |
Median [IQR] difference in eggs per gram of stool between baseline and month 6 | −52.8 [−24 to −81.6] *All eggs cleared at 6 months |
−21.6 [−4.8 to −72] *All but 2 cleared eggs at 6 months |
−33.6 [−9.6 to −52.8] *All eggs cleared at 6 months |
n/a | 0* |
Median [IQR] 6-month Mayo score | 2 [0-2] | 2 [2-4] | 2 [2-3] | 2 [0-2] | 2 [0-2] |
Median [IQR] difference in Mayo score between baseline and month 6 | − 2 [−1 to −3] | 0 [+2 to −0] | −0.5 [+1 to −1.5] | 0 [0 to −2] | 0 [0 to +2] |
All newly infected people were diagnosed by CAA only.
Representative pre-post gastrointestinal mucosal findings in three individuals are shown in Figure 3. These individuals demonstrated examples of mucosal changes that occurred in those with improvement, worsening, or no change in the severity of mucosal abnormalities.