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. 2023 Jan 29;16:16. doi: 10.1186/s12920-023-01436-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Flow chart for the SMR analysis. A SMR analysis using eQTL data from CAGE; and B SMR analysis using eQTL data from GTEx. eQTL, expression quantitative trait loci; GWAS, genome-wide association studies; LD, linkage disequilibrium; SMR, summary data-based Mendelian randomization; SNP, single nucleotide polymorphisms