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. 2023 Jan 28;13:1613. doi: 10.1038/s41598-023-28643-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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An example overview of the processing used in this methodology. The graph on the left side of the figure demonstrates the change in relative T₁ or R₂^* observed in a DSC/DCE experiment. The graph on the left demonstrates the signal time course of [1-¹³C]pyruvate (blue) and subsequent exchange to [1-¹³C]lactate (brown) observed in a hyperpolarized experiment. The text shows the flow of data from each experiment for the Metabolic Clearance Rate formalism.