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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Pediatr Res. 2022 Jul 29;93(2):316–323. doi: 10.1038/s41390-022-02206-5

Figure 1. miRNA processing and activity.

Figure 1.

Both messenger RNA and pri-micro-ribonucleic acids (miRNAs) are transcribed from the genome inside the nucleus. After the microprocessor complex converts pri-miRNA to a precursor miRNA complex, it is exported outside the nucleus by Exportin 5. The enzyme, Dicer, processes precursor miRNA into its single-stranded mature form, it can be loaded into the RNA-induced silencing complex. This complex facilitates binding with complementary messenger RNA molecules, preventing translation into proteins by ribosomes.