Table 4.
Logistic Regression Analyses of YKL-40 with White Matter Hyperintensity
| YKL-40 | Overall WMH | PV-WMH | D-WMH | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Unadjusted model | ||||||
| First quartile | Reference | Reference | Reference | |||
| Second quartile | 1.154 (0.752–1.770) | 0.513 | 1.273 (0.827–1.958) | 0.273 | 0.975 (0.630–1.510) | 0.911 |
| Third quartile | 1.024 (0.667–1.571) | 0.913 | 0.976 (0.632–1.506) | 0.912 | 0.904 (0.583–1.403) | 0.654 |
| Fourth quartile | 1.210 (0.789–1.857) | 0.383 | 2.456 (1.583–3.810) | 0.001 | 0.975 (0.630–1.510) | 0.911 |
| Age- and sex-adjusted | ||||||
| First quartile | Reference | Reference | Reference | |||
| Second quartile | 1.150 (0.673–1.964) | 0.610 | 1.385 (0.786–2.440) | 0.260 | 0.933 (0.565–1.540) | 0.785 |
| Third quartile | 1.217 (0.714–2.075) | 0.469 | 1.189 (0.678–2.086) | 0.545 | 1.025 (0.620–1.695) | 0.924 |
| Fourth quartile | 0.790 (0.458–1.362) | 0.396 | 2.595 (1.434–4.697) | 0.002 | 0.699 (0.421–1.162) | 0.167 |
| Multivariable adjusted* | ||||||
| First quartile | Reference | Reference | Reference | |||
| Second quartile | 1.124 (0.649–1.945) | 0.677 | 1.318 (0.733–2.369) | 0.356 | 0.897 (0.539–1.493) | 0.676 |
| Third quartile | 1.171 (0.679–2.021) | 0.570 | 1.107 (0.614–1.995) | 0.736 | 1.052 (0.631–1.752) | 0.847 |
| Fourth quartile | 0.762 (0.434–1.336) | 0.343 | 2.473 (1.316–4.646) | 0.005 | 0.695 (0.413–1.171) | 0.172 |
Notes: *Overall WMH: adjusted for age, gender, hypertension, previous stroke, TOAST subtype, and FBG. PV-WMH: adjusted for age, gender, hypertension, previous stroke, drinking, TOAST subtype, TG, FBG, and Hs-CRP. D-WMH: adjusted for age, gender, hypertension, previous stroke or TIA, smoking, TOAST subtype, and FBG.
Abbreviations: WMH, white matter hyperintensity; PV-WMH, periventricular white matter hyperintensity; D-WMH, deep white matter hyperintensity; OR, odds ratio; CI, confidence interval.