Table 1.

Summary of PCOS-IR–associated Mt-tRNA mutations

tRNA species	Allele	Nucleotide position in tRNAs	Structure location	Homoplasmy/heteroplasmy	Aberrant tRNA Biology	References
tRNALeu(UUR)	C3275T	44	Variable region	Homoplasmy	Disrupts conserved base-pairing	[69]
	A3302G	71	Acceptor arm	Heteroplasmy	Affects 3’-end processing	[65]
tRNAGln	T4363C	38	Anticodon stem	Homoplasmy	Affects tRNA posttranscriptional modification	[69]
	T4395C	6	Acceptor arm	Homoplasmy	Creates new base-pairing	[69]
tRNACys	G5821A	6	Acceptor arm	Homoplasmy	Disrupts conserved base-pairing	[75,76]
tRNASer(UCN)	C7492T	26	Anticodon stem	Homoplasmy	Creates new base-pairing	[52]
tRNAAsp	A7543G	29	Anticodon stem	Heteroplasmy	Affects tRNA aminoacylation and steady-state level	[71]
tRNALys	A8343G	54	TψC loop	Homoplasmy	Affects tRNA posttranscriptional modification	[69]
tRNAGlu	A14693G	54	TψC loop	Homoplasmy	Affects tRNA posttranscriptional modification	[46,71]