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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Reprod Toxicol. 2022 Mar 17;109:121–134. doi: 10.1016/j.reprotox.2022.03.007

Fig. 9.

Fig. 9.

Cr(VI) increased acetyl-p53:SIRT1 co-localization and ratio in the ovary of F1 offspring. Cr(VI) increased the co-localization of acetyl-p53 and SIRT1 in the germ cells and somatic cells of the PND1 ovary. Pregnant dams were treated with or without Cr(VI) (10 ppm) through drinking water from 9.5–14.5 days post-coitum (dpc). On postnatal day (PND) 1, F1 offspring were euthanized, and ovaries were processed for immunofluorescence. Representative images of the ovaries are shown from control (A - p53; B - SIRT1; C - Merge) and Cr(VI) (D - acetyl p53; E - SIRT1; F - Merge). Histograms show acetyl-p53:SIRT1 co-localization (G) and p53:SIRT1 ratio (H). I - Negative control. * Control vs. Cr(VI) (p<0.05).