Fig. 1. Myocardial energy metabolism in diabetic heart disease. The heart in diabetes (both type 1 and type 2) experiences several perturbations in intermediary energy metabolism. In particular, the heart in an individual with diabetes produces the majority of its energy (ATP) from the mitochondrial oxidation of fatty acids (right half of the figure), which comes at the expense of a severe impairment in the mitochondrial oxidation of carbohydrates (i.e., glucose) (left half of the figure). This figure was created with BioRender.com.