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. 2022 Nov 17;12(1):37–46. doi: 10.12997/jla.2023.12.1.37

Fig. 3. Pelacarsen is an ASO targeting the mRNA of the LPA gene. Binding of the ASO results in mRNA degradation through RNAse H. Olpasiran is a siRNA. The antisense strand combines with RISC and targets LPA mRNA for degradation. The inhibition of LPA mRNA translation by pelacarsen and olpasiran results in decreased production of Apo(a) and Lp(a).

Fig. 3

ASO, antisense oligonucleotide; siRNA, small interfering RNA; RISC, RNA-induced silencing complex; Apo, apolipoprotein; Lp(a), lipoprotein (a); GalNAc, N-acetylgalactosamine.