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. 2023 Jan 23;220(4):e20220686. doi: 10.1084/jem.20220686

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© 2023 Sun et al.

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Figure 1. — STAT3 promotes the effector function of CD8⁺ T cells. (A) Mean volumes of B16-OVA tumors (left panel) in Stat3^fl/fl (n = 6) and Stat3^fl/flCd8a^Cre (n = 6) mice, or E.G7 tumors (right panel) in Stat3^fl/fl (n = 7) and Stat3^fl/flCd8a^Cre (n = 6) mice. (B) Numbers of CD8⁺ T cells in TDLNs and tumors from Stat3^fl/fl and Stat3^fl/flCd8a^Cre mice. (C) Representative plots (left panel) and quantifications (right panel) of IFN-γ and Granzyme B production in CD44⁺PD-1⁺ CD8⁺ TILs from B16-OVA (left panel) or E.G7 (right panel) tumors. (D) Experimental design for adoptive cotransfer of naive WT and Stat3^−/− OT-I cells and B16-OVA tumor–challenge assay. (E) OT-I TIL frequencies among total CD8⁺TILs from B16-OVA tumors on day 14 and day 20 after tumor inoculation. (F) Representative plots (left panel) and quantifications (right panel) of IFN-γ and Granzyme B production in OT-I TILs from B16-OVA tumors. (G) Frequencies of OVA-specific CD8⁺ T cells and their numbers (P = 0.0590) in LM-OVA–infected Stat3^fl/fl and Stat3^fl/flCd8a^Cre mice on day 8. (H) Representative plots (left panel) and quantifications (right panel) of IFN-γ and Granzyme B production in splenic CD44⁺ CD8⁺ T cells on day 8 after LM-OVA infection. Data are representative of two (A [left], B [left], C [left], G, and H) or three (A [right], B [right], C [right], and D–F) independent experiments. Data are shown as mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001 by two-way ANOVA (A), unpaired two-tailed Student’s t test (B, C, G, and H), or paired two-tailed Student’s t test (E and F).