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. 2023 Jan 30;8:44. doi: 10.1038/s41392-022-01264-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Single-cell landscape of cervical cancer pre- and post-RCT. a Schematic overview of the strategy of scRNA-seq in this study. b Validation cohort 1 (15 pairs of pre-RCT and post-RCT CC samples for IHC) and cohort 2 (20 pairs of pre-RCT and post-RCT bulk RNA-seq data). c Uniform manifold approximation and projection (UMAP) visualization of all identified cell clusters. Colors represent cell types (left panel), sample origin (middle panel), and individual samples (right panel). d Box plots showing the relative fold change in the abundance of each cell cluster compared between pre- and post-RCT samples. The colors of dots and squares represent individual patients and sample groups, respectively. The p values correspond to the paired Wilcoxon tests. e UMAP visualization of the 5 Epi subclusters in all (left panel), pre-RCT (middle panel), and post-RCT samples (right panel). f Bar plots showing the relative proportions of the 5 Epi subclusters in all epithelial cells in pre/post-RCT samples. g Box plots showing the relative fold change in the abundance of each Epi cell cluster compared between pre- and post-RCT samples. The colors of dots and squares represent individual patients and sample groups, respectively. The p values correspond to the paired Wilcoxon tests