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. 2023 Jan 30;8:44. doi: 10.1038/s41392-022-01264-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Clinical role of cell subclusters and cell-cell interactions. a Correlation between the abundance of cell subclusters (CIBERSORTx analysis) and patient survival in 295 TCGA bulk RNA-seq data of CC samples (Cox regression analysis). Adjusted p values were obtained using Benjamini & Hochberg adjustment method to control the false discovery rate for multiple comparisons. b Circos plot showing the cell-cell interactions in cell clusters pre- (top panel) and post-RCT (bottom panel). The thickness of each string indicates the number of different interaction pairs colored by cell clusters. c Summary of chemokine ligand-receptor interactions between cell clusters in pre-RCT (left panel) and post-RCT samples (right panel)