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. 2023 Jan 30;8:40. doi: 10.1038/s41392-022-01219-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Administration of gentamicin alleviated the pathogenesis of psoriasis-like skin phenotype in K14-VEGF mice with the decreased infiltration of Th17. a Macroscopic characteristics of the ears in Control and Genta group mice 4–5 M (18 weeks). b PASI score of ears in Control and Genta group mice. c Representative H&E staining of ears (Scale bars: 50 μm). d Pathological score of ear sections using the Baker scoring system. e Average epidermal thickness. f–i Relative mRNA expression of IL-17A, IL-23, S100A7, and KRT10 in the ears of Control and Genta group mice. j Analysis of Th17 cells (CD4⁺ IL-17⁺) by flow cytometry in ears. k Number of Th17 cells in ears. l Representative fluorescence in situ hybridization for Prevotella (Prv392) in colonic contents. m Analysis of Th17 cells (CD4⁺ IL-17⁺) by flow cytometry in DLNs. n Percentage of Th17 cells in CD4⁺ cells. o Representative fluorescence in situ hybridization for Parabacteroides distasonis (PD) in colonic contents. Data presented as mean ± SD on relevant graphs. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.005 (Two-tailed Student’s t-test). (n = 6)