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. 2023 Jan 30;8:40. doi: 10.1038/s41392-022-01219-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The administration of PDE-4 inhibitors significantly improved psoriasis-like skin phenotype in K14-VEGF mice and was accompanied by recovery of intestinal microbiota. a Macroscopic characteristics of the ears in Vehicle and PDE-4 inhibitor group mice in 0 week and 6 weeks. b Improvement percentages of PASI score of ears in Vehicle and PDE-4 inhibitor group mice from 0 week to 6 weeks. c Taxonomic distributions of bacteria. d PcoA of unweighted UniFrac distance based on 16s rDNA profiling of feces from Vehicle and PDE-4 inhibitor group mice. e, f Relative abundance of Parabacteroides distasonis and Prevotella in the feces of Vehicle and PDE-4 inhibitor group mice. Data presented as mean ± SD on relevant graphs. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.005 (two-tailed Student’s t-test) (n = 3)