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. 2023 Jan 16;13:1069741. doi: 10.3389/fendo.2022.1069741

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Copyright © 2023 Vezzoli, Hrvat, Goggi, Federici, Cangiano, Quinton, Persani and Bonomi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genes reported in CHH and SLDP are related to GnRH development and GnRH function. The drawing on the left panel shows the migration of the GnRH neurons from the olfactory placode and into the hypothalamus which occurs within the first 10 to 12 weeks of rodent life. In the right panel, a concise view of our current understanding of the KISS1 neuronal networks governing GnRH secretion is depicted. Genes associated with CHH are depicted in red, shared genes between CHH and SLDP are depicted in green whereas genes related to SLDP are marked in orange. GnRH, gonadotropin-releasing hormone; KNDy, Kiss1/NKB/Dyn neuron; ARC, arcuate nucleus; AVPV, anteroventral periventricular nucleus; EM, median eminence.