Table 2.
Irisin inducer that have been studied in relation to longevity pathways
| Inducers | Pathway boosted | Target cells/tissue | Effects | References |
|---|---|---|---|---|
| Icariin | AMPK | C2C12 myocytes, mice | Decrease body weight gain | 57 |
| Ampelopsin | AMPK/SIRT1/PGC-α | Rat skeletal muscle | Attenuate atrophy | 58 |
| Genistein | AMPK | Adipose tissue | Browning | 21 |
| Metformin | SIRT1 | INS-1E cells Obese mice |
Improve pancreatic cells survival | 74, 75 |
| Resveratrol | UCP-1, SIRT1 | Muscle, adipose tissue | Improve the glycaemic and lipid profiles | 78, 79 |
| Vitamin D | SIRT1 | human | Decrease glycosylated haemoglobin | 80 |
| Omega-3 | Diabetic human | No results yet | 81 | |
| Cardamom | Diabetic human | No results yet | 82 |