Table 4.
Partial drug clinical trials in progress or in preparation (data from ClinicalTrials.gov).
| Drugs | Population | Clinical trial registration number | Phase of clinicial trail | Status | |
|---|---|---|---|---|---|
| GLP-1RAs | Semaglutide | NASH | NCT04822181 | 3 | Recruiting |
| T2DM with NAFLD | NCT05067621 | 3 | Not yet recruiting | ||
| Semaglutide and NNC0194-0499(a new medicine which works in the liver) /NNC0174-0833 (a novel weight-loss medicine) |
NASH | NCT05016882 | 3 | Recruiting | |
| Tirzepatide (LY3298176) | NASH | NCT04166773 | 2 | Recruiting | |
| PPRA--α/γ agonist | Lanifibranor | T2DM with NASH | NCT03459079 | 2 | Recruiting |
| NASH | NCT04849728 | 3 | Recruiting | ||
| THR-β agonist | MGL-3196 | NAFLD | NCT04951219 | 3 | Recruiting |
| NASH | NCT03900429 | 3 | Recruiting | ||
| NASH | NCT02912260 | 2 | Unknown | ||
| Fatty acid synthase inhibitors | TVB-2640 | NASH | NCT04906421 | 2 | Active, not recruiting |
| A3AR | Namodenoson | NASH | NCT04697810 | 2b | Recruiting |
| GLP-1/GIP/Glucagon triple agonist | HM15211 | NASH | NCT04697810 | 2 | Recruiting |
| Oligonucleotide drugs targeting Patatin-like PNPLA3 gene | AZD2693 | NASH | NCT04166773 | 2 | Recruiting |
| lipid nanoparticle drug containing siRNA that inhibits HSP47 | BMS-986263 | NASH | NCT04267393 | 2 | Recruiting |
| novel insulin sensitizer target mitochondrial pyruvate carriers | MSDC-0602K | T2DM with NAFLD/NASH | NCT03970031 | 3 | Recruiting |
| β-Klotho/FGFR1c receptor agonist | MK-3655 (NGM313) | NASH | NCT04583423 | 2b | Recruiting |