Table 1.
The interaction between miRNAs and UPS in NSCLC.
| MIRNA | E3/DUBS | Target proteins | Reaction axis | Function | Reference |
|---|---|---|---|---|---|
| miR-138-5p | TRIM65 | TNRC6A | TRIM65/TNRC6A/MiR-138-5P/ATG7 | Promotes cisplatin resistance | (98) |
| miR-195/miR-497 | SMURF2 | TβRI | miR-195,miR-497/SMURF2/TβRI/TGF-β/SMAD | Promotes proliferation, invasion and xenograft tumor growth | (99) |
| miR-520b | SPOP | GLI2/3 | miR-520b/SPOP/GLI2/3/Hh | Promotes proliferation and migration | (100) |
| miR-135b | CYLD | RIP1 | IL-6/STAT3/miR-135b/CYLD/RIP1/NF-κB | Promotes migration, invasion, angiogenesis, xenograft tumor growth and anti-apoptosis | (101) |
| miR-101-3p |
USP47
MDM2 |
RPL11 P53 |
miR-101-3p/USP47/RPL11/MDM2/P53 | Suppresses proliferation | (102) |
| miR-30-5p | USP22 | HIF-1α | miR-30-5p/USP22
/HIF-1α/PD−L1 |
Suppresses immune evasion | (103) |
| miR-320b | USP37 | CDT1 | miR-320b/USP37/CDT1 | Suppresses proliferation, invasion and xenograft tumor | (104) |
| miR-365 | USP33 | ROBO1 | miR-365/USP33/SLIT2-ROBO1 | Promotes proliferation, migration, invasion and xenograft tumor growth | (105) |
| miR-489-3p | USP48 | β-catenin | miR-489-3p/USP48/β-catenin/Wnt | Promotes proliferation, invasion, migration and xenografted tumor growth and metastasis | (106) |