Table 2.
The interaction between lncRNAs and UPS in NSCLC(when a protein acts as two roles, the two charts were merged).
| LncRNAs | E3/DUBS | Ce/RBP/… | Target proteins | Reaction axis | Function | Reference |
|---|---|---|---|---|---|---|
| VAL | TRIM16 | Vimentin | AKT/STAT3/VAL/Vimentin-TRIM16/EMT | Promotes invasion and migration | (115) | |
| HOXC-AS3 | MDM2 | YBX1 | HOXC-AS3/YBX1-MDM2/HOXC8 | Promotes proliferation, migration, invasion, xenografted tumor growth and metastasis | (116) | |
| OXCT1-AS1 | NARF | LEF1 | OXCT1-AS1/LEF1-NARF/EMT | Promotes migration, invasion and xenografted tumor metastasis | (117) | |
| FAM83A-AS1 | CRLs | HIF-1α | FAM83A-AS1/HIF-1α- VHL-CRLs |
Promotes migration, invasion, stemness and glycolysis | (118) | |
| LNBC3 | FBXO11 | BCL6 | ASO/LNBC3/BCL6-FBXO11 | Promotes migration and xenografted tumor growth | (119) | |
| ALAL-1 | USP4 | SART3 | ALAL-1/SART3-USP4/NF-κB | Promotes immune evasion and proliferation | (120) | |
| GIAT4RA | Uchl3 | LSH | GIAT4RA/LSH-UCHL3 | Suppresses proliferation migration, invasion, xenografted tumor growth and metastasis | (121) | |
| RMST | FBW7 | SOX9 | RMST/SOX9-FBW7 | Suppresses proliferation, migration and xenografted tumor growth | (122) | |
| LINC01426 | USP22 | SHH | LINC01426/USP22/SHH | Promotes proliferation, migration, and stemness but suppresses apotosis | (123) | |
| lncKLF6 | BMI1 | H2A | lncKLF6/USP22-BMI1/KLF6 | Promotes proliferation cell cycle, and xenografted tumor growth but suppress apotosis | (124) | |
| SNHG16 | USP21 | miR-4500 | YY1 | USP21/YY1/SNHG16/miR-4500 | Promotes proliferation, migration, and invasion | (125) |
| PKMYT1AR | SCFβ-TrCP | miR-485-5p | β-catenin | ASO/PKMYT1AR/miR-485-5p/PKMYT1/SCFβ-TrCP/β-catenin/WNT | Promotes proliferation, migration, cell cycle, cancer stem cell maintenance and chemo- or radio-therapy resistance, but suppress apotosis | (126) |
| SNHG12 | USP8 | HuR | PD-L1 | SNHG12/HuR/USP8/PD-L1 | Promotes proliferation and immune escape but suppress apotosis | (127) |