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. 2023 Jan 26;10(1):e001468. doi: 10.1136/bmjresp-2022-001468

Table 2.

Relation between diffusion parameters and clinical, functional and morphological variables in subjects with smoking history of more than 10 pack-years*

DLCO, z-score DLCO/VA, z-score
R P value R P value
Age, years 0.017 0.829 −0.079 0.303
BMI, kg/m2 0.127 0.097 0.295 <0.001
Pack-years −0.054 0.478 −0.041 0.595
Fagerström test −0.291 0.010 −0.270 0.017
Charlson index 0.020 0.799 0.103 0.179
COTE index −0.115 0.134 0.010 0.892
CAT total score −0.194 0.011 −0.084 0.271
mMRC dyspnoea scale −0.299 0.565 0.041 0.938
Baseline SaO2, % 0.093 0.227 0.046 0.549
Exhaled CO, ppm −0.370 <0.001 −0.302 <0.001
Prebronchodilator FVC, z-score 0.352 <0.001 −0.136 0.074
Prebronchodilator FEV1, z-score 0.393 <0.001 −0.023 0.7666
Prebronchodilator FEV1/FVC, z-score 0.148 0.053 0.194 0.011
6MWD, m 0.206 0.007 0.020 0.793
Haemoglobin, g/L 0.087 0.261 0.117 0.133
Eosinophils, % 0.041 0.599 0.154 0.047
Fibrinogen, g/L −0.073 0.390 −0.098 0.248
C reactive protein, mg/L −0.079 0.326 −0.020 0.800
Albumin, g/L 0.295 0.182 −0.114 0.613
BODE index −0.020 0.791 0.174 0.023
YPAS—physical activity summary 0.218 0.043 0.148 0.175
Total emphysema volume, % 0.020 0.812 −0.064 0.440
Low density volume, % 0.050 0.547 −0.021 0.801
P15, HU −0.089 0.280 −0.038 0.650
Secondary bronchi WA, % 0.002 0.978 0.008 0.926
Pulmonary artery diameter, mm −0.294 <0.001 −0.381 <0.001
Pulmonary artery:aorta ratio 0.027 0.748 0.082 0.321

Bold values highlight significant relationships.

*Pearson correlation coefficient (r) and p value are shown.

BMI, body mass index; BODE, Body Obstructive Dyspnoea Exercise; CAT, Chronic Obstructive Pulmonary Disease Assessment Test; CO, carbon monoxide; COTE, Chronic obstructive pulmonary disease-specific co-morbidity test; DLCO, lung diffusing capacity of carbon monoxide; FEV1, forced expiratory volume at 1 s; FVC, forced vital capacity; HU, hounsfield units; mMRC, modified Medical Research Council; 6MWD, 6 min walk distance; P15, 15th percentile; SaO2, oxygen saturation; VA, alveolar volume; WA, wall area; YPAS, Yale Physical Activity Survey.