Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 24;11(1):e005518. doi: 10.1136/jitc-2022-005518

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

BCG instillations induce epigenetic modifications in genes involved in autophagy, IL-1β, and epigenetic enzymes. Results of the ChIP-sequencing analysis. (A) UCSC genome browser tracks of H3K4me3 signal found around the TNF gene locus of a NMIBC patient with good clinical response to BCG. (B) H3K4me3 signal near the TNF gene locus of a patient who had a recurrence after BCG therapy. H3K4me3 signal is displayed for pre-BCG1, BCG6, pre-BCG7, BCG9 and pre-BCG10. (C) Volcano plot of ChIP-sequencing data. The x-axis displays the fold change (in log2) in H3K4me3 signal between pre-BCG1 and any of the post-BCG time points (BCG6, pre-BCG7, BCG9 and pre-BCG10; see online supplemental table 4). The y-axis displays the p value adjusted for multiple testing using the Benjamini-Hochberg method. The red line indicates an adjusted p value of 0.05. ChiP, chromatin immuno precipitation; NMIBC, non-muscle invasive bladder cancer; UCSC, University of California Santa Cruz.