Figure 8.
Micrographs of the colon (A-D) and histological score of all groups (E). H & E sections of colon from mice exposed to TMA intraperitoneally (C) and intrarectally (D) or negative control (A) or vehicle control (B) are shown. Severe inflammation characterized by severe cellular infiltration persisted in the colon of mice exposed to TMA intrarectally (D) compared to negative and vehicle control. Black star point to cellular infiltration, red star points to damaged muscularis, yellow star points to increased lumen and red triangle points to distorted crypts. The histology scores for the inflammation of these groups are summarized in (E). The histological score showed a significant increase in inflammation after TMA exposure. *p<0.05.