Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 16;12:1082062. doi: 10.3389/fonc.2022.1082062

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Vallero, Bertero, Morana, Sciortino, Bertin, Mussano, Ricci, Peretta and Fagioli

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Histopathological and molecular findings of a representative diffuse midline glioma, H3 K27-altered (WHO 2021). (A) Hematoxylin and eosin image (original magnification: 100X) showing a diffuse, infiltrative glioma with astrocytic morphology. (B) Diffuse expression of OLIG2, a glial marker, is consistent with this tumor type. (C) Loss of H3K27me3 is present and exemplifies a mandatory diagnostic feature. (D) Sanger sequencing output showing a K27M mutation (arrow), the most frequent molecular alteration observed in this tumor type.