Table 1.
Correlation analysis between MTHFD2 and immune biomarkers by TIMER and TCGA databases.
| Cell type | Gene marker | BRCA TIMER | BRCA TCGA | ||||
|---|---|---|---|---|---|---|---|
| None | Purity | cor | p | ||||
| cor | p | cor | p | ||||
| B cell | CD19 | 0.048 | 0.114 | 0.105 | **** | 0.028 | 0.353 |
| CD79A | 0.057 | 0.058 | 0.131 | **** | 0.047 | 0.114 | |
| Th1 | IFNG | 0.198 | **** | 0.264 | **** | 0.180 | **** |
| STAT1 | 0.345 | **** | 0.374 | **** | 0.347 | *** | |
| STAT4 | 0.073 | * | 0.151 | **** | 0.051 | 0.092 | |
| TBX21 | 0.080 | ** | 0.164 | **** | 0.069 | 0.022 | |
| Th2 | GATA3 | -0.243 | **** | -0.284 | **** | -0.198 | **** |
| STAT6 | -0.209 | **** | -0.188 | **** | -0.156 | **** | |
| STAT5A | -0.191 | **** | -0.168 | **** | -0.158 | **** | |
| IL13 | 0.114 | **** | 0.131 | **** | 0.038 | 0.209 | |
| CD8+T cell | CD8A | 0.091 | ** | 0.175 | **** | 0.104 | **** |
| CD8B | 0.077 | ** | 0.157 | **** | 0.088 | ** | |
| T cell | CD3D | 0.033 | 0.271 | 0.110 | **** | 0.038 | 0.203 |
| CD3E | 0.048 | 0.108 | 0.132 | **** | 0.050 | 0.098 | |
| CD2 | 0.103 | **** | 0.190 | **** | 0.096 | *** | |
| M1 Macrophages | PTGS2 | 0.055 | 0.070 | 0.112 | **** | 0.044 | 0.145 |
| IRF5 | -0.035 | 0.243 | -0.022 | 0.057 | -0.042 | 0.164 | |
| NOS2 | 0.046 | 0.129 | 0.049 | * | 0.083 | ** | |
| M2 Macrophages | MS4A4A | 0.175 | **** | 0.237 | **** | 0.156 | **** |
| VSIG4 | 0.074 | * | 0.112 | **** | 0.083 | ** | |
| CD163 | 0.243 | **** | 0.294 | **** | 0.217 | **** | |
| Dendritic cell | ITGAX | 0.065 | 0.031 | 0.112 | **** | 0.029 | 0.339 |
| NRP1 | 0.032 | 0.283 | 0.077 | * | 0.030 | 0.316 | |
| CD1C | -0.141 | **** | -0.107 | **** | -0.133 | **** | |
| NK cell | KIR2DS4 | 0.098 | *** | 0.142 | **** | 0.081 | ** |
| KIR3DL3 | 0.114 | **** | 0.101 | *** | 0.088 | ** | |
| KIR3DL2 | 0.112 | **** | 0.168 | **** | 0.145 | **** | |
| KIR3DL1 | 0.082 | ** | 0.154 | **** | 0.134 | **** | |
| Neutrophils | CCR7 | 0.062 | * | 0.139 | **** | 0.059 | * |
| ITGAM | 0.013 | 0.677 | 0.034 | 0.288 | 0.029 | 0.336 | |
| CEACAM8 | 0.035 | 0.242 | 0.028 | 0.385 | -0.033 | 0.270 | |
| Tfh | BCL6 | -0.127 | **** | -0.117 | **** | -0.122 | **** |
| IL21 | 0.195 | **** | 0.234 | **** | 0.241 | **** | |
| Th17 | STAT3 | 0.061 | * | 0.07 | * | 0.104 | **** |
| IL17A | 0.117 | **** | 0.141 | **** | 0.100 | **** | |
| Treg | FOXP3 | 0.225 | **** | 0.290 | **** | 0.196 | **** |
| CCR8 | 0.317 | **** | 0.363 | **** | 0.294 | **** | |
| STAT5B | -0.120 | **** | -0.109 | **** | -0.101 | **** | |
| TGFB1 | -0.216 | **** | -0.198 | **** | -0.174 | **** | |
| Mast cell | TPSB2 | -0.323 | **** | -0.311 | **** | -0.293 | **** |
| TPSAB1 | -0.315 | **** | -0.301 | **** | -0.287 | **** | |
| CPA3 | -0.183 | **** | -0.161 | **** | -0.184 | **** | |
| MS4A2 | -0.174 | **** | -0.155 | **** | -0.192 | **** | |
| HDC | -0.222 | **** | -0.202 | **** | -0.232 | **** | |
*p<0.05, **p<0.01, ***p<0.001, and ****p<0.0001.