TABLE V.
The generated variables of the proposed model, which are significantly associated with increased/decreased risk of progression, their short names, description, log hazard ratios as well as p-values.
| Cluster Number | Short Name | Description | Coefficient | p-value |
|---|---|---|---|---|
| C_0 | GN and OrganTx | Acute and chronic glomerulonephritis (GN), vasculitides, polycystic kidney disease, acute kidney injury, hypertensive chronic kidney disease, as well as solid organ transplant (Organ TX, kidney, heart, lung) | 0.36 | <0.001 |
| C_1 | Diabetes | Diabetes mellitus type 1 and 2 with and without diabetic ketoacidosis and hyperosmolarity | 0.18 | <0.001 |
| C_11 | HTN | Hypertensive heart and chronic kidney disease and malignant hypertension (HTN) | 0.17 | <0.001 |
| C_12 | Obesity and Sleep Apnea | Obesity, metabolic syndrome, sleep apnea, and other disorders | −0.11 | 0.01 |
| C_14 | BMI | Measurements of BMI (body mass index) over 25 | 0.18 | 0.006 |
| C_15 | Spine and Nerve | Spondyloarthropathies and neuropathies | −0.17 | 0.01 |
| C_16 | Hips, Eyes, and Skin | Hip arthropathies, ophthalmologic, dermatologic, polymyalgia rheumatica, giant cell arteritis, depression, and impotence | −0.21 | <0.001 |
| C_2 | Anemia and GI | Anemia and Upper and lower gastrointestinal (GI) tract diagnoses including esophagitis, gastritis, duodenitis, diverticulosis/-itis, and hemorrhoids | 0.11 | 0.01 |
| C_22 | Thyroid | Thyroid and parathyroid diagnoses including: hypothyroidism, thyroiditis, goiter, and non-renal hyperparathyroidism | −0.16 | 0.048 |
| C_24 | Psychiatric | Psychiatric (bipolar, schizophrenia, major depression) and substance abuse (opioid, cocaine, amphetamines, marijuana) | −0.19 | <0.001 |
| C_28 | Benign Gyn and Family Hx | Allergies to antibiotics, lipoma, benign gynecological (GYN) conditions such as post-menopausal bleeding, tubal ligation family history (Hx), urge incontinence, and leiomyomatous uterus, as well a family histories of solid tumor and hematologic malignancies | −0.12 | 0.033 |
| C_29 | Asthma | Asthma and viral pneumonias including influenza | −0.33 | 0.002 |
| C_41 | Hematuria and DNR | Hematuria, thrombocytopenia, refusal of vaccination, do not resuscitate (DNR) status, physical restraint status, and being overweight | 0.24 | <0.001 |
| C_43 | Multiple Myeloma | Monoclonal paraproteinemia, plasma cell neoplasm, hypercalcemia, and pathologic fractures | 0.31 | 0.042 |
| C_5 | Sepsis | Acute kidney injury related to severe sepsis and shock, disseminated bacterial and yeast infections, resulting in organ failure and respiratory failure and complications of tracheostomy and gastrostomy | 0.35 | <0.001 |
| C_6 | Hematuria2 and Hematologic | Hematuria, lower urinary tract symptoms, unspecified renal failure, dysphagia, ascites, aplastic anemia, neoplasm of uncertain behavior neutropenia, adrenal insufficiency | −0.29 | <0.001 |
| C_9 | Cirrhosis | Liver disease and cirrhosis including hepatorenal syndrome from alcohol, autoimmune, and viral hepatitis | 0.25 | <0.001 |