TABLE 1.
Comparison of clinical data among NC group, T2DM group, and DFU group [n (%), ( ± s), M (P25, P75)]
| Variable | NC group (n = 60) | T2DM group (n = 64) | DFU group (n = 82) | P value |
|---|---|---|---|---|
| Male [n (%)] | 33 (55.0) | 34 (53.1) | 44 (53.7) | .795 |
| Age (year) | 52.1 ± 8.9 | 53.3 ± 8.7 | 52.6 ± 8.5 | .308 |
| Duration of diabetes (year) | ‐ | 0.4 ± 0.2 | 11.7 ± 5.8 | <.001 |
| Ulcer duration (week) | ‐ | ‐ | 7.8 ± 2.4 | ‐ |
| Ulcer area (cm2) | ‐ | ‐ | 10.7 ± 3.6 | ‐ |
| SBP (mm Hg) | 119 ± 9 | 123 ± 12 | 125 ± 13 | .103 |
| DBP (mm Hg) | 73 ± 12 | 76 ± 13 | 77 ± 11 | .361 |
| FPG (mmol/L) | 4.9 ± 0.5 | 9.7 ± 2.3b | 11.5 ± 3.3bd | <.001 |
| HbA1c (%) | 5.2 ± 0.3 | 8.2 ± 1.4b | 9.4 ± 1.4bd | <.001 |
| TG (mmol/L) | 1.5 ± 0.7 | 1.7 ± 0.5a | 1.8 ± 0.7b | .031 |
| TCH (mmol/L) | 4.3 ± 0.7 | 4.9 ± 0.6 | 4.7 ± 0.5 | .187 |
| LDL‐C (mmol/L) | 2.5 ± 0.2 | 3.2 ± 0.4 | 2.6 ± 0.3 | .096 |
| HDL‐C (mmol/L) | 1.4 ± 0.2 | 1.2 ± 0.3a | 0.9 ± 0.4bd | <.001 |
| ABI | 1.1 ± 0.1 | 1.0 ± 0.1 | 0.8 ± 0.2bd | <.001 |
| CRP (mg/L) | 6.3 ± 0.9 | 8.7 ± 1.1 | 30.5 ± 2.4bd | <.001 |
| WBC (×109) | 4.3 ± 0.7 | 4.6 ± 0.8 | 10.2 ± 2.2bd | <.001 |
| ESR (mm/h) | 10.3 ± 2.2 | 12.6 ± 2.8 | 45.7 ± 15.9bd | <.001 |
| P‐miR‐204‐3p | 3.27 (1.51‐6.98) | 2.38 (1.31‐5.04)a | 1.15 (0.78‐2.89)bd | <.001 |
| T‐miR‐204‐3p | ‐ | ‐ | 2.29 (1.11‐4.57) | ‐ |
| T‐KLF6 | ‐ | ‐ | 2.924 (1.47‐4.02) | ‐ |
Note: Data are presented mean ± standard deviations or numbers (%) or median with IQR; Differences among four groups analysed using one‐way analysis of variance or x 2 test, and the SNK‐q test analysis was used for comparison between the two groups. Versus NC group, a P < .05, b P < .01; vs T2DM group, c P < .05, d P < .01. T‐miR‐204‐3p, miR‐204‐3p expression in the wound margin tissue; T‐KLF6, KLF6 mRNA expression in the wound margin tissue.
Abbreviations: ABI, ankle brachial index; CRP, C‐reactive protein; DBP, diastolic blood pressure; DFU, diabetic foot ulcer; ESR, erythrocyte sedimentation rate; FPG, fasting plasma glucose; HbA1c, glycated haemoglobin A1c; HDL‐C, high‐density lipoprotein cholesterol; LDL‐C, low‐density lipoprotein cholesterol; MiR, MicroRNA; NC, normal control; P‐miR‐204‐3p, plasma miR‐204‐3p expression; SBP, systolic blood pressure; T2DM, type 2 diabetes; TCH, total cholesterol; TG, triacylglycerol; WBC, white blood cell.