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. Author manuscript; available in PMC: 2023 Oct 24.
Published in final edited form as: J Med Chem. 2022 Nov 2;65(22):15327–15343. doi: 10.1021/acs.jmedchem.2c01299

Figure 7.

Figure 7.

15-PGDH inhibitors accelerate recovery following bone marrow transplantation. Mice were irradiated at day-1 and dosing with vehicle or drug was initiated. (+)-4 was dosed in vehicle 1 (10% EtOH, 5% cremophor EL, 85% D5W, pH 7.4. 49 was dosed in vehicle 2 (10% DMSO, 25% PEG 400, 1% Tween-80, 64% D5W, pH 7.6). On day 0, 106 bone marrow cells were injected IV and drug or vehicle administration was continued twice daily. Circulating neutrophils were counted at days 10 and 15 (n =10 – 16 per group). *P < 0.05, **P < 0.005.