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. 2023 Jan 25;9(2):217–227. doi: 10.1021/acscentsci.2c01359

Figure 4.

Figure 4

Compound WU-04 also inhibited the 3CLpro of SARS-CoV and MERS-CoV. (a, d) WU-04 but not WU-06 inhibited the enzyme activity of SARS-CoV 3CLpro (a) and MERS-CoV 3CLpro (d). The data represent the mean ± SD of three independent measurements. (b, e) Close-up view of the binding modes of WU-04 to SARS-CoV 3CLpro (b) and MERS-CoV 3CLpro (e). WU-04 is colored cyan. Hydrogen bonds are represented by yellow dash lines. (c, f) The antiviral activity of WU-04 against SARS-CoV (c) or against MERS-CoV (f) was measured in Calu-3 cells. The data represents the mean ± SD of three independent measurements.