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In vivo efficacy of WU-04 against a mouse-adapted SARS-CoV-2 variant in mice. (a) Schematic diagram of the study process. (b, c) After three-day treatment with WU-04 or the vehicle control, the viral RNA copy numbers (b) and the viral titers (c) in the nasal turbinate and lung of each mouse were determined. There were six mice in each group. * P < 0.05, **** P < 0.0001.
